Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis
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Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis
Harmine is a natural compound possessing insulin-sensitizing effect in db/db diabetic mice. However its effect on adipose tissue browning is unknown. Here we reveal that harmine antagonizes high fat diet-induced adiposity. Harmine-treated mice gained less weight on a high fat diet and displayed increased energy expenditure and adipose tissue thermogenesis. In vitro, harmine potently induced the...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep36382